DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma
Simar Pal Singh, Kumar Mangalam, Michelle D van den Beukel, Sjoerd J. van Deventer, Marije B. Overdijk, M. Guy Roukens, Kim C. M. Santegoets, Esther C.W. Breij, Martin ter Beest, Willem PJ Cox, Annemiek B. van Spriel
This study shows that DuoHexaBody-CD37 induces direct cytotoxicity in DLBCL cells through CD37 clustering and signaling changes, independent of subtype.
eLife · Jul 20, 2026Peer-reviewedCancer Biology