Annemiek B. van Spriel

Multiple mechanisms regulate the nanoscale organization of PD-L1 at the cell surface

This study investigates how PD-L1 is organized into nanoscale clusters on tumor cell surfaces and identifies actin cytoskeleton, galectin-3, and cholesterol as key regulators of its spatial arrangement and function.

Metabolic regulation of cytokine responses in diffuse large B-cell lymphoma

This study investigates how metabolic pathways influence cytokine production in diffuse large B-cell lymphoma, finding that glycolysis modulation affects IL-6, IL-10, and TNFα levels and that DLBCL subtypes respond differently to IL-4.

TSPAN3 defines a distinct intracellular trafficking route to secretory multivesicular bodies

This study identifies TSPAN3 as a marker of a distinct secretory multivesicular body population with unique trafficking and EV composition compared to CD63-positive compartments.

DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

This study shows that DuoHexaBody-CD37 induces direct cytotoxicity in DLBCL cells through CD37 clustering and signaling changes, independent of subtype.

Tetraspanin CD82 reduces the formation of CADM1 oligomers

This study shows CD82 reduces CADM1 oligomer formation by interacting with its extracellular domains, affecting transmembrane helix spacing and disrupting cell adhesion.

Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation

This study shows that galectin-9 in dendritic cells is necessary for organizing HLA-II at immune synapses, which enhances CD4+ T cell activation and anti-tumor immunity.

Small molecule inhibitor combination treatment effectively represses global B-cell signaling in diffuse large B-cell lymphoma

The paper shows that combining three inhibitors represses B-cell signaling more effectively than single inhibitors in diffuse large B-cell lymphoma.