Author

Matthew J. McGuffie

The University of Texas at AustinORCID 0000-0002-2903-4154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

Jeffrey E. BarrickiD· 2 shared Dennis M. MishleriD· 1 shared Diya BhatiD· 1 shared Genevieve A. MortenseniD· 1 shared Joseph J. Clements· 1 shared Noor Radde· 1 shared Sean P. LeonardiD· 1 shared Shireen Shah· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersSynthetic Biology

Jeffrey E. BarrickORCID

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2 papers

Recent·Most cited

Measuring the burden of hundreds of BioBricks defines an evolutionary limit on constructability in synthetic biology

Noor Radde, Genevieve A. Mortensen, Diya Bhat, Shireen Shah, Joseph J. Clements, Sean P. Leonard, Matthew J. McGuffie, Dennis M. Mishler, Jeffrey E. Barrick

The paper measures the growth burden of 301 BioBricks in E. coli and finds that 19.6% reduce growth, with most burdens explained by gene expression resource diversion.

Nature Communications · Jul 24, 2024Peer-reviewedSynthetic Biology

Identifying widespread and recurrent variants of genetic parts to improve annotation of engineered DNA sequences

Matthew J. McGuffie, Jeffrey E. Barrick

The paper identifies 217 uncatalogued genetic part variants in engineered plasmids, highlighting widespread and convergent changes that may affect scientific reproducibility.

PLoS ONE · May 28, 2024Peer-reviewedSynthetic Biology