Kainate receptors are critical for permissivity to sustained, disorganized, and network-wide pathological activity in the epileptic dentate gyrus
Lucas Goirand-Lopez, Pascal Benquet, Mariam Al Harrach, Bruno Delord, Valérie Crépel
This study shows that kainate receptors (KARs) enable sustained pathological activity in the epileptic dentate gyrus by altering network dynamics and promoting disorganized firing patterns.
bioRxiv · Apr 1, 2026 · PreprintNeuroscience