Valérie Crépel

This study shows that kainate receptors (KARs) enable sustained pathological activity in the epileptic dentate gyrus by altering network dynamics and promoting disorganized firing patterns.

This study shows that a somatic MTOR variant in FCD type II causes hyperexcitability through overactivation of GluN2C NMDA receptors in rat neurons.

This study shows that dysmyelination in specific hippocampal interneurons affects their excitability and spatial memory, but not all interneuron types.

This study demonstrates that gene therapy targeting GluK2 reduces seizures in TLE models and patient-derived slices.

The paper shows that mature dentate granule cells have different intrinsic excitability based on the behavioral context of their activation.