Philippe Fauré

This paper introduces a method to control endogenous nicotinic receptors in mice using light-activated drug release, revealing circuit-specific effects previously hidden by systemic administration.

This study shows that isogenic female mice form stable social hierarchies, with high-ranked females showing greater sociability and different dopamine and glucocorticoid receptor signaling compared to males.

This study shows that the interpeduncular nucleus (IPN) regulates nicotine reward by modulating VTA neuron activity through β4-containing nAChRs.

This study shows that dopaminergic activity in the ventral tegmental area shapes social roles and labor division in mouse triads through competitive and cooperative strategies.

The paper shows dopamine stabilizes reward-related neural attractors and guides behavior by activating them online in mice.

This study investigates the role of dopamine D2 autoreceptors in regulating VTA dopamine neuron responses to aversive stimuli and finds they act as a regulatory brake with sex-biased effects on threat processing.

The paper shows nicotine inhibits amygdala-projecting dopamine neurons via a VTA-NAc feedback loop, leading to anxiety.

This study shows that dopamine signals in the nucleus accumbens reflect dynamic representation learning during adaptive decision-making in mice.

This study shows that adolescent nicotine exposure disrupts dopamine circuit development, leading to adult vulnerability to nicotine, which can be reversed by restoring dopamine pathway balance.

The paper studies individual differences in reward-seeking behavior among isogenic mice in a social environment and links these differences to nicotine response and dopaminergic adaptability.

The paper investigates how mice generate self-initiated goal-directed choices through interactions between the ventral tegmental area, prefrontal cortex, and orbitofrontal cortex.

This study shows that SWI/SNF chromatin remodelers are essential for behavioral and transcriptional adaptations to stress and cocaine, with gene inactivation leading to resilience and reduced gene expression.

This study shows chronic nicotine exposure shifts decision-making strategies toward increased exploitation in a foraging task, with optogenetic manipulation of dopamine neurons replicating this effect.

This study identifies distinct dopamine circuits in the ventral tegmental area that mediate nicotine's reinforcing and anxiogenic effects through opposing responses in neurons projecting to the nucleus accumbens and amygdala.

This study shows that loss of floor plate Netrin-1 disrupts corticospinal tract midline crossing in mice, causing mirror movements similar to human congenital conditions.

This study demonstrates that the GluD2 receptor functions as an ion channel using genetically-engineered photopharmacology, showing light-controlled modulation of its activity.

This study shows mice generate choice variability in a deterministic task through memory-free, pseudo-random selection rather than learning complex sequences.

This study shows that somatic nicotinic acetylcholine receptors in VTA dopamine neurons modulate firing properties and reward-related behaviors through optical manipulation.

The paper shows that social interactions shape individuality in mice by altering dopaminergic system adaptations and behavioral traits.

This study shows that phasic dopamine activity, modulated by acetylcholine receptors, predicts exploratory behavior and uncertainty-seeking in mice during decision-making tasks.