A microscopy reporter for cGAMP reveals rare cGAS activation following DNA damage, and a lack of correlation with micronuclear cGAS enrichment
Vivianne Lebrec, Negar Afshar, Lauren R. Davies, Tomoya Kujirai, Αλεξάνδρα Κανέλλου, Federico Tidu, Christian Zierhut
The paper introduces a cGAMP reporter to visualize cGAS activation in response to DNA damage and finds that cGAS activation is limited to a subfraction of cells and not correlated with micronuclear cGAS enrichment.
bioRxiv · May 13, 2024 · PreprintCell Biology