Physiological basis underlying antidepressant-induced activation of TrkB receptors
Okko Alitalo, Samuel Kohtala, Marko Rosenholm, Piia Kohtala, Roosa Saarreharju, Nobuaki Matsui, Gemma González-Hernández, Heidi Kaastrup Müller, Wiebke Theilmann, Mirkka P. Sarparanta, Anders Bue Klein, Olli K. Kärkkäinen, Stanislav V. Rozov, Tomi Rantamäki
This study shows that antidepressants activate TrkB receptors through physiological changes like hypothermia and reduced energy expenditure, not just pharmacological action.
bioRxiv · Aug 30, 2021 · PreprintNeuroscience