Inge M. M. Lakeman

Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9

This study identifies biallelic germline variants in MCM8 and MCM9 as linked to polyposis, gastric cancer, early-onset colorectal cancer, and hypogonadism, with MCM9 variants showing stronger associations.

A new inverse probability of selection weighted Cox model to deal with outcome-dependent sampling in survival analysis

The paper introduces a new inverse probability of selection weighted Cox model to correct for outcome-dependent sampling bias in survival analysis, demonstrating its effectiveness through simulations and real datasets.

Breast cancer risks associated with missense variants in breast cancer susceptibility genes

The paper assesses breast cancer risks linked to rare missense variants in five susceptibility genes using logistic and mixture models, finding varying risk contributions across genes.