Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations
Elham Gholizadeh, Ehsan Zangene, Uladzislau Vadadokhau, Danilo Ritz, Juho Jalmari Miettinen, Rabah Soliymani, Marc Baumann, Mathias Wilhelm, Esko M Kankuri, Paul A. Haynes, Caroline Akemi Heckman, Amir Ata Saei, Mohieddin Jafari
This paper introduces CoPISA, a proteomics workflow that identifies combination-specific protein targets in AML, revealing conjunctional targeting mechanisms beyond classical drug synergy.
Nature Communications · Mar 25, 2026Peer-reviewedBiochemistry