Esko M Kankuri

Chemical Proteomics of Residual Acute Myeloid Leukemia Cells Reveals Therapeutic Vulnerabilities

This study uses CoPISA and proteomics to analyze venetoclax-azacitidine response in AML cells, identifying adaptive vulnerabilities like NRP2.

Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations

This paper introduces CoPISA, a proteomics workflow that identifies combination-specific protein targets in AML, revealing conjunctional targeting mechanisms beyond classical drug synergy.

Small molecule activation of m6A mRNA methylation as a novel approach for neuroprotection

The paper identifies small molecule activators of m6A mRNA methylation that protect and regenerate dopamine neurons in Parkinson's disease models.

Small-molecule inhibitors of the RNA m6A demethylase FTO potently support the survival of dopamine neurons

This study develops small-molecule FTO inhibitors that enhance dopamine neuron survival and show BBB penetration, with greater potency than existing AlkBH5 inhibitors.

Epicardial therapy with atrial appendage micrografts salvages myocardium after infarction

This study evaluates the effectiveness of atrial appendage micrografts delivered epicardially to salvage myocardium after infarction in a mouse model, showing reduced fibrosis and increased cardiac regeneration-associated proteins.