Plasmid copy number affects the DNA methylation-driven expression dynamics of the CfrBI restriction-modification system and impacts phage restriction
Johannes Gibhardt, Trung Duc Hoang, Konstantin Severinov…·Natalia Evgenevna Morozova
This study shows that plasmid copy number affects the expression dynamics and phage resistance of the CfrBI R-M system, with medium-copy plasmids providing the highest resistance.