Author

Joseph Brealey

ORCID 0000-0002-3013-9375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Ben PeacockiD· 2 shared Alexandros Marios SofiasiD· 1 shared Danilo MladenovićiD· 1 shared Josbert M. MetselaariD· 1 shared Kairi KoortiD· 1 shared Marek WeileriD· 1 shared Martin DulleiD· 1 shared Nataša ZarovniiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Ben PeacockORCID

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2 papers

Recent·Most cited

Lipid nanoparticle shape and morphology determine the magnitude and duration of mRNA transfection

Sara Elsafy, Martin Dulle, Saba Shahzad, Thomas Hammoor, Marek Weiler, Ben Peacock, Joseph Brealey, Josbert M. Metselaar, Twan Lammers, Alexandros Marios Sofias

This study shows that LNP shape and morphology affect mRNA transfection efficiency and duration, with non-spherical LNPs showing higher expression despite similar uptake to spherical ones.

bioRxiv · Oct 22, 2026 · PreprintPharmacology & Toxicology

Quantitative fluorescent nanoparticle tracking analysis and nano-flow cytometry enable advanced characterization of single extracellular vesicles

Danilo Mladenović, Joseph Brealey, Ben Peacock, Kairi Koort, Nataša Zarovni

This paper standardizes fluorescent analysis of extracellular vesicles using nanoparticle tracking analysis and nano-flow cytometry with reference materials, enabling accurate quantification of marker abundance and heterogeneity.

Journal of Extracellular Biology · Jan 1, 2025Peer-reviewedCell Biology