Twan Lammers

This study shows that LNP shape and morphology affect mRNA transfection efficiency and duration, with non-spherical LNPs showing higher expression despite similar uptake to spherical ones.

This study shows that nanoparticle size affects their uptake by myeloid cells and delivery to hematopoietic organs in myeloproliferative neoplasms.

This study shows that melatonin nanoparticles reduce myeloproliferative neoplasm symptoms by targeting metabolic, inflammatory, and fibrotic pathways.

This study identifies Spp1⁺ macrophages as key hubs coordinating fibrotic remodeling in myeloproliferative neoplasms using NicheSphere, a novel computational method for cell communication analysis.

The paper shows that Wnt-dependent reprogramming of bone marrow niches drives fibrosis by activating osteolineage cells and altering hematopoietic support.