Marek Weiler

Lipid nanoparticle shape and morphology determine the magnitude and duration of mRNA transfection

This study shows that LNP shape and morphology affect mRNA transfection efficiency and duration, with non-spherical LNPs showing higher expression despite similar uptake to spherical ones.

Oncodevelopmental plasticity of the skeleton in myeloid neoplasms

This study identifies a novel mechanism in myelofibrosis where a single mutation drives both bone formation and resorption, revealing THBS1 as a therapeutic target.

Wnt-dependent spatiotemporal reprogramming ofbone marrow niches drives fibrosis

The paper shows that Wnt-dependent reprogramming of bone marrow niches drives fibrosis by activating osteolineage cells and altering hematopoietic support.