Certain Aquatic Eukaryotes Harbor an OLD-Like Immune Defense System
The paper identifies old-like genes in certain aquatic eukaryotes, suggesting a potential antiviral defense system evolutionarily related to prokaryotic anti-phage systems.
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Université LavalORCID 0000-0002-3026-5339Unclaimed ORCID profile · follow to get notified of new preprints
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The paper identifies old-like genes in certain aquatic eukaryotes, suggesting a potential antiviral defense system evolutionarily related to prokaryotic anti-phage systems.
The paper identifies eight gurmarin-like peptides from Gymnema sylvestre and shows that Gur-1 and Gur-2 interact with the T1R2/T1R3 sweet taste receptor, suggesting potential for antidiabetic drug development.
The paper identifies mutations N764K and N856K in the SARS-CoV-2 Omicron BA.1 S protein that create potential cleavage sites for SKI-1/S1P protease, potentially altering tissue tropism and pathogenesis.
C.S. Berger, Jérôme Laroche, Halim Maaroufi…·Nadia Aubin‐Horth
The paper identifies proteins secreted by Schistocephalus solidus that may manipulate its host, with some proteins being species-specific.
Halim Maaroufi, Marianne Potvin, Michel Cusson, Roger C. Lévesque
This paper identifies novel anionic cecropins in the spruce budworm with a poly-L-aspartic acid C-terminus, showing structural and functional differences from conventional cationic cecropins and suggesting potential anticancer activity.
The paper identifies a PPxY late domain motif in SARS-CoV-2's spike protein that may enhance viral budding and spread, potentially making it a target for antiviral therapeutics.
The paper identifies LxxIxE-like motifs in SARS-CoV-2 spike protein that recruit PP2A-B56 and suggests Artepillin C as a potential inhibitor to combat inflammation in COVID-19.
Laura Benestan, Jean‐Sébastien Moore, Ben J. G. Sutherland…·Louis Bernatchez
The paper shows that unbalanced sex ratios and sex-linked markers can cause false genetic differentiation signals in population studies, highlighting the need for sex information in genomic analyses.