GenomicsNature CommunicationsPeer-reviewed
Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging
Hagit Masika, Shmuel Ruppo, Stephen J. Clark…·Howard Cedar
The paper identifies average polycomb CpG methylation as a hallmark of cellular aging using single-cell whole-genome methylation data, showing cell-to-cell variability and accelerated aging in faster proliferating cells.
2 citations