Efrat Katsman

Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging

The paper identifies average polycomb CpG methylation as a hallmark of cellular aging using single-cell whole-genome methylation data, showing cell-to-cell variability and accelerated aging in faster proliferating cells.

Improved deconvolution of circulating tumor DNA from ultra-low-pass whole-genome methylation sequencing using CelFiE-ISH

This study improves ctDNA deconvolution in ULP-WGS data using CelFiE-ISH, achieving lower cancer fraction detection limits than CNA benchmarks.

Multi-cell type deconvolution using a probabilistic model for single-molecule DNA methylation haplotypes

This paper develops a probabilistic model for cell type deconvolution using single-molecule DNA methylation haplotypes, showing improved accuracy in detecting rare cell types.

Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing

This study demonstrates the ability to detect cell-of-origin and cancer-specific methylation features from cell-free DNA using Oxford Nanopore sequencing.