Author

Hagit Masika

Hebrew University of Jerusalem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Oriya VardiiD· 2 shared Abraham ZlotogorskiiD· 1 shared Alejandro Aguilera-CastrejoniD· 1 shared Amnon KoreniD· 1 shared Asaf ZviraniD· 1 shared Britny Blumenfeld· 1 shared Dalia Elinger· 1 shared Daoud Sheban· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenomics

Oriya VardiORCID

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3 papers

Recent·Most cited

Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging

Hagit Masika, Shmuel Ruppo, Stephen J. Clark, Marc Jan Bonder, Ferdinand von Meyenn, Merav Hecht, Shari Orlanski, Efrat Katsman, Oriya Vardi, Abraham Zlotogorski, Tahel Fachler, Sharona Elgavish, Yuval Dor, Wolf Reik, Tommy Kaplan, Howard Cedar

The paper identifies average polycomb CpG methylation as a hallmark of cellular aging using single-cell whole-genome methylation data, showing cell-to-cell variability and accelerated aging in faster proliferating cells.

Nature Communications · Jun 9, 2026Peer-reviewedGenomics

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Nofar Mor, Yoach Rais, Daoud Sheban, Shani Peles, Alejandro Aguilera-Castrejon, Asaf Zviran, Dalia Elinger, Sergey V. Viukov, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Elad Chomsky, Lior Lasman, Tom Shani, Jonathan Bayerl, , Jacob H. Hanna

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

Cell stem cell · Aug 16, 2018Peer-reviewedDevelopmental Biology

Germline DNA replication timing shapes mammalian genome composition

Yishai Yehuda, Britny Blumenfeld, Nina Mayorek, Kirill Makedonski, Oriya Vardi, Leonor Cohen‐Daniel, Yousef Mansour, Shulamit Sebban, Hagit Masika, Marganit Farago, Michael F. Berger, Shai Carmi, Yosef Buganim, Amnon Koren, Itamar Simon

The paper measures DNA replication timing in mouse germline cells and shows it strongly correlates with mutation rates, recombination hotspots, and genomic features compared to somatic tissues.

Nucleic Acids Research · Jun 26, 2018Peer-reviewedGenomics