Oriya Vardi

Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging

The paper identifies average polycomb CpG methylation as a hallmark of cellular aging using single-cell whole-genome methylation data, showing cell-to-cell variability and accelerated aging in faster proliferating cells.

Stage-specific metabolic rewiring coordinates nucleotide supply and demand during spermatogenesis

The paper defines metabolic programs during spermatogenesis by analyzing transcriptomic, proteomic, and metabolic changes across meiotic stages.

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

The paper analyzes 2,787 tumors to show that replication timing and mutation rate association is influenced by both cell autonomous and non-autonomous processes, including DNA repair, chromatin structure, and immune cell interactions.

Cancer mutational processes vary in their association with replication timing and chromatin accessibility

The paper analyzes mutational signatures in tumors to determine their association with replication timing and chromatin accessibility, finding signature-specific associations and clinical relevance of SBS16 in liver cancer.

Germline DNA replication timing shapes mammalian genome composition

The paper measures DNA replication timing in mouse germline cells and shows it strongly correlates with mutation rates, recombination hotspots, and genomic features compared to somatic tissues.