Ferdinand von Meyenn

This study examines the epigenetic effects of prolonged fasting in humans, finding changes in DNA methylation and epigenetic aging clocks linked to metabolic responses.

The paper identifies average polycomb CpG methylation as a hallmark of cellular aging using single-cell whole-genome methylation data, showing cell-to-cell variability and accelerated aging in faster proliferating cells.

This paper provides a framework for selecting and understanding validation metrics for subpopulation detection in single-cell and spatial omics data, developing new metrics and implementing them in a Bioconductor package.

This study uses patient-derived neurons to show mitochondrial dysfunction in MMA leads to neuronal exhaustion and altered excitability.

The paper shows that DNA methylation ageing is reflected in correlations between genomic loci, with a preference for 500 bp apart sites, and links this to PRC2-dependent H3K27me3 dilution.

The paper identifies epigenetically primed enhancers in early embryonic development and shows their role in regulating developmental gene networks across species.

The paper benchmarks computational methods for analyzing scATAC-seq data, finding that SnapATAC and SnapATAC2 outperform other methods in cell-type discrimination and scalability.

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

This study induces in vivo reprogramming in C. elegans and finds it leads to heterogeneous effects on lifespan depending on developmental stage.

This study compares mouse strains for in vivo reprogramming to develop safer strategies and create a comprehensive atlas of reprogrammable strains.

This paper develops an aging clock using chromatin accessibility data from PBMCs and shows it correlates with transcriptional changes during aging.

GwEEP quantifies DNA modifying enzyme efficiencies using HPoxBS data, revealing dynamic changes in methylation and hydroxylation during cellular reprogramming and development.

This study characterizes the molecular changes in the mouse hippocampus during the acute stress response using multiomic profiling and identifies rapid resolution of molecular events within 4 hours.

IMPLICON is a high-throughput method for measuring DNA methylation at imprinted regions with high coverage and resolution, validated in mice and adapted for human use to detect imprinting errors.

This paper demonstrates that tankyrase inhibition enables efficient, transgene-free reprogramming of human somatic cells to naive pluripotency, with clonal expansion and differentiation capabilities.

The paper introduces an open-source platform for high-throughput nucleic acid extraction and manipulation using magnetic beads, highlighting their cost-effectiveness and versatility.

This paper describes a method to reset human pluripotent stem cells to a naive state through transient histone deacetylase inhibition, showing transcriptomic and epigenomic changes similar to the inner cell mass.

The paper develops a DNA methylation age predictor for mice, showing it accurately measures biological age and responds to interventions like ovariectomy and diet.