Author

Carl M. Vitzthum

Harvard UniversityORCID 0000-0002-3075-2305Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:database / resource· 2 Approach:experimental assay· 2 Assay:Hi-C· 2 Research Focus:software / tool· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Organism:human· 1

Frequent Co-Authors

Peter J. ParkiD· 5 shared B. AlveriD· 3 shared Soohyun LeeiD· 3 shared Alison R. BartoniD· 2 shared Christopher A. WalshiD· 2 shared Clara BakkeriD· 2 shared Jeremy JohnsoniD· 2 shared Koray KırlıiD· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBioinformatics

Peter J. ParkORCID

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Author profile →

5 papers

Recent·Most cited

The 4D Nucleome Data Portal: a resource for searching and visualizing curated nucleomics data

Sarah B. Reiff, Andrew J. Schroeder, Koray Kırlı, Andrea Cosolo, Clara Bakker, Luisa Mercado, Soohyun Lee, Alexander D. Veit, Alexander K. Balashov, Carl M. Vitzthum, William Ronchetti, Kent M. Pitman, Jeremy Johnson, Shannon R. Ehmsen, Peter Kerpedjiev, , Peter J. Park

The paper introduces the 4DN Data Portal, a resource for searching and visualizing curated nucleomics data, including Hi-C and other chromosome architecture datasets.

Nature Communications · May 2, 2022Peer-reviewedGenomics

Pairs and Pairix: a file format and a tool for efficient storage and retrieval for Hi-C read pairs

Soohyun Lee, Clara Bakker, Carl M. Vitzthum, B. Alver, Peter J. Park

The paper introduces Pairs, a compressed file format for Hi-C read pairs, and Pairix, a tool for indexing and querying these files, along with a quality control tool.

Bioinformatics · Dec 28, 2021Peer-reviewedBioinformatics

Tibanna: software for scalable execution of portable pipelines on the cloud

Soohyun Lee, Jeremy Johnson, Carl M. Vitzthum, Koray Kırlı, B. Alver, Peter J. Park

Tibanna automates bioinformatics pipeline execution on AWS using CWL, WDL, and Docker, supporting large-scale and variable computational needs.

Bioinformatics · Apr 30, 2019Peer-reviewedBioinformatics

Aging and neurodegeneration are associated with increased mutations in single human neurons

Michael A. Lodato, Rachel E. Rodin, Craig L. Bohrson, Michael E. Coulter, Alison R. Barton, Min‐Seok Kwon, Maxwell A. Sherman, Carl M. Vitzthum, Lovelace J. Luquette, Chandri Yandava, Pengwei Yang, Thomas W. Chittenden, Nicole E. Hatem, Steven C. Ryu, Mollie B. Woodworth, , Christopher A. Walsh

The paper identifies age-related accumulation of somatic mutations in human neurons and links them to neurodegenerative diseases.

Science · Dec 7, 2017Peer-reviewedGenomics

PaSD-qc: Quality control for single cell whole-genome sequencing data using power spectral density estimation

Maxwell A. Sherman, Alison R. Barton, Michael A. Lodato, Carl M. Vitzthum, Michael E. Coulter, Christopher A. Walsh, Peter J. Park

PaSD-qc evaluates scWGS library quality using power spectral density to assess amplification uniformity and identify aberrant chromosomes.

Nucleic Acids Research · Nov 17, 2017Peer-reviewedBioinformatics