Soohyun Lee

The paper introduces the 4DN Data Portal, a resource for searching and visualizing curated nucleomics data, including Hi-C and other chromosome architecture datasets.

The paper introduces Pairs, a compressed file format for Hi-C read pairs, and Pairix, a tool for indexing and querying these files, along with a quality control tool.

This study identifies de novo and polymorphic retrotransposon insertions in ASD families, finding increased exonic and intronic insertions in ASD cases compared to controls.

HiTea uses Hi-C data to detect non-reference transposable element insertions, outperforming whole genome sequencing-based methods in human cell lines.

HiNT detects copy number variations and translocations from Hi-C data with single base-pair resolution, outperforming existing methods on simulated and real data.

Tibanna automates bioinformatics pipeline execution on AWS using CWL, WDL, and Docker, supporting large-scale and variable computational needs.

HiGlass, a web-based, containerized viewer, enables continuous multiscale navigation of Hi-C contact maps alongside genomic tracks using composable views linked by location and zoom.