Author

Jan Oppelt

University of PennsylvaniaORCID 0000-0002-3076-4840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Nicholas VrettosiD· 2 shared Abdias Diaz‐RosadoiD· 1 shared Annabel K. SangreeiD· 1 shared Ansgar ZochiD· 1 shared Ashley J. Melendez-PereziD· 1 shared Brian SongiD· 1 shared Dana E. Layo-CarrisiD· 1 shared Dónal O’CarrolliD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenetics

Nicholas VrettosORCID

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Author profile →

2 papers

Recent·Most cited

TBCK Deficiency Alters Ribosomal Function, RNA Splicing, and miRNA Networks: Insights from Multi-Omics Analyses

Abdias Diaz‐Rosado, Kelly Clark, Rajesh Angireddy, Michael B. Gilbert, Annabel K. Sangree, Jan Oppelt, Nicholas Vrettos, Emily L. Durham, Elizabeth M. Gonzalez, Emily E. Lubin, Ashley J. Melendez-Perez, Dana E. Layo-Carris, Kaitlin A. Katsura, Elizabeth J. K. Bhoj

This study uses multi-omics analyses to show that TBCK deficiency disrupts ribosomal function, RNA splicing, and miRNA networks in TBCK-/- cells, providing insights into the molecular mechanisms of the disorder.

bioRxiv · Sep 23, 2025 · PreprintGenetics

MIWI arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis

Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O’Carroll, Zissimos Mourelatos

This study shows that MIWI arginines are essential for spermatogenesis by regulating transposons, piRNA amplification, and spermiogenic transcript stabilization.

bioRxiv · Dec 31, 2023 · PreprintMolecular Biology