Author

Zissimos Mourelatos

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Research Focus:software / tool· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Manolis MaragkakisiD· 2 shared Nicholas VrettosiD· 2 shared Panagiotis AlexiouiD· 2 shared Anastassios VourekasiD· 1 shared Ansgar ZochiD· 1 shared Brian D. GregoryiD· 1 shared Brian SongiD· 1 shared Dónal O’CarrolliD· 1 shared

Activity by Year

2015-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersDevelopmental Biology

Manolis MaragkakisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MIWI arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis

Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O’Carroll, Zissimos Mourelatos

This study shows that MIWI arginines are essential for spermatogenesis by regulating transposons, piRNA amplification, and spermiogenic transcript stabilization.

bioRxiv · Dec 31, 2023 · PreprintMolecular Biology

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

Yongjuan Guan, Hongyan Gao, Nicolae Adrian Leu, Anastassios Vourekas, Panagiotis Alexiou, Manolis Maragkakis, Zhenlong Kang, Zissimos Mourelatos, Guanxiang Liang, P. Jeremy Wang

This study shows MOV10 restricts LINE1 retrotransposition in mice in a dosage-dependent manner, affecting reproductive fitness and transcriptome regulation.

PLoS Genetics · May 1, 2023Peer-reviewedDevelopmental Biology

Isolation and sequencing of AGO-bound RNAs reveals characteristics of mammalian stem-loop processing in vivo

Ian M. Silverman, Sager J. Gosai, Nicholas Vrettos, Shawn W. Foley, Nathan Berkowitz, Zissimos Mourelatos, Brian D. Gregory

The paper isolates and sequences AGO-bound RNAs to study pre-miRNA processing in human and mouse cells, identifying novel pre-miRNAs and processing characteristics.

bioRxiv · Apr 6, 2018 · PreprintMolecular Biology

GenOO: A Modern Perl Framework for High Throughput Sequencing analysis

Manolis Maragkakis, Panagiotis Alexiou, Zissimos Mourelatos

GenOO is a Perl framework for HTS analysis that models biological entities as objects, enabling flexible and efficient development of custom tools.

bioRxiv · Nov 3, 2015 · PreprintBioinformatics