Dónal O’Carroll

The paper determines the structure of the apo-PIWIL4-HSP90 complex and shows it adopts an open conformation distinct from piRNA-bound PIWI.

This study investigates whether HSP90AA1 variants cause autosomal dominant male infertility in humans and finds that while some variants are associated with infertility, their pathogenicity remains uncertain.

This paper introduces a double reporter strategy to identify a non-migratory subset of hematopoietic stem cells in the bone marrow niche and shows their dynamic interactions during stress and aging.

This study shows PROSER1 regulates DNA demethylation through dual mechanisms, balancing gene expression and preventing developmental malformations.

This study shows that MIWI arginines are essential for spermatogenesis by regulating transposons, piRNA amplification, and spermiogenic transcript stabilization.

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.

The paper identifies terminal uridylyltransferases as a conserved antiviral mechanism in animals by uridylating viral RNA to promote degradation.