A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function
Pranav Kumar, Navid Tahan Zadeh, Zulfeqhar Ali Syed, Hayley M. Reynolds, Duy T. Tran, Liping Zhang, Kelly G. Ten Hagen, Nadine L. Samara
This study identifies a single amino acid difference in PGANT5 isoforms that affects substrate specificity and salivary gland function in Drosophila.
bioRxiv · Dec 24, 2025 · PreprintBiochemistry