Zulfeqhar Ali Syed

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

BLOC1S1 regulates autolysosomal and exosomal dynamics during CD4⁺ T cell differentiation

This study shows BLOC1S1 deficiency in CD4+ T cells leads to altered lysosomal and exosomal dynamics, enhancing Th2 immune responses through exosome-mediated cytokine export.

ENDOTHELIAL PROX1 INDUCES BLOOD-BRAIN BARRIER DISRUPTION IN THE CENTRAL NERVOUS SYSTEM

This study shows that endothelial Prox1 overexpression disrupts the blood-brain barrier by downregulating BBB-associated genes and Wnt/β-catenin signaling during both embryonic and postnatal stages.

A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function

This study identifies a single amino acid difference in PGANT5 isoforms that affects substrate specificity and salivary gland function in Drosophila.