Rafael Samaniego

This study identifies G-CSF as a prognostic biomarker in melanoma and shows it promotes metastasis by enhancing tumor cell invasion and macrophage pro-tumoral activity.

This study shows that GM-CSF expression in melanoma and tumor-associated macrophages correlates with poor prognosis and promotes metastasis through pro-inflammatory signaling.

This study shows that modulating GSK3 activity reprograms GM-CSF-dependent macrophages to exhibit features of M-CSF-dependent macrophages and interstitial macrophages.

The paper identifies inflammatory cytokine-producing TAMs and PD-L1 tumor expression as poor prognosis factors in cutaneous melanoma using single-cell RNA sequencing and microscopy.