Electrostatic Complementarity at the ClpX Substrate-EntryChannel Governs ATP-Driven Protein Unfolding
Yifei Lyu, Naseer Iqbal, Alireza Ghanbarpour
The paper shows that electrostatic complementarity between ClpX's positively charged substrate-entry channel and substrate domains determines ATP-driven protein unfolding efficiency.
bioRxiv · Aug 3, 2026 · PreprintBiochemistry