Author

Sergio Alejandro Poveda Cuevas

Goethe University FrankfurtORCID 0000-0002-3087-6674Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Catherine EtchebestiD· 2 shared Fernando Luís Barroso da SilvaiD· 2 shared Ivan ĐikićiD· 2 shared Ramachandra M. BhaskaraiD· 2 shared Alberto CristianiiD· 1 shared Aparna Viswanathan AmmanathiD· 1 shared Belinda CampiD· 1 shared Borna MarkusiciD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Catherine EtchebestORCID

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Author profile →

4 papers

Recent·Most cited

TBK1 restricts IRGQ-mediated autophagy

Uxía Gestal Mato, Pauline Lascaux, Sergio Alejandro Poveda Cuevas, Alberto Cristiani, Belinda Camp, Mahyar Aghapour, Aparna Viswanathan Ammanath, Ramachandra M. Bhaskara, Ivan Đikić, Lina Herhaus

This study identifies TBK1 as a regulator of IRGQ-mediated autophagy by disrupting the IRGQ-GABARAPL2 complex through phosphorylation of GABARAPL2.

Nature Communications · May 13, 2026Peer-reviewedBiochemistry

Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy

Sergio Alejandro Poveda Cuevas, Kateryna O. Lohachova, Borna Markusic, Ivan Đikić, Gerhard Hummer, Ramachandra M. Bhaskara

This study investigates the role of intrinsically disordered regions (IDRs) in ER-phagy by modeling and simulating their membrane interactions and remodeling effects.

Proceedings of the National Academy of Sciences · Oct 25, 2024Peer-reviewedBiophysics

NS1 from Two Zika Virus Strains Differently Interact with a Membrane: A Plausible Explanation for their Differential Virulence

Sergio Alejandro Poveda Cuevas, Fernando Luís Barroso da Silva, Catherine Etchebest

The paper compares membrane interactions of NS1 proteins from two Zika virus strains to explain their differential virulence using molecular dynamics simulations.

Journal of Chemical Information and Modeling · Feb 13, 2023Peer-reviewedBioinformatics

Self-association features of NS1 proteins from different flaviviruses

Sergio Alejandro Poveda Cuevas, Catherine Etchebest, Fernando Luís Barroso da Silva

The paper examines the self-association of NS1 proteins from Zika, Dengue, and West Nile viruses using biophysical simulations, revealing pH-dependent oligomerization and distinct interaction profiles.

Virus Research · May 31, 2022Peer-reviewedBioinformatics