Author

Pauline Lascaux

Goethe University FrankfurtORCID 0000-0003-3935-6795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alberto CristianiiD· 1 shared Alvin Wei Tian NgiD· 1 shared Andrea PierangeliniiD· 1 shared Aparna Viswanathan AmmanathiD· 1 shared Belinda CampiD· 1 shared Christopher J. LordiD· 1 shared Cynthia X. Hou· 1 shared Darragh Patrick O'BrieniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Alberto CristianiORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cell BiologyNature Cell BiologyPeer-reviewedJun 1, 2026

Nucleophagy removes cytotoxic trapped PARP1

Gwendoline Hoslett, Sara Tribble, Pauline Lascaux…·Kristijan Ramadan

This study identifies nucleophagy as the mechanism by which trapped PARP1 is cleared, showing that inhibiting this process re-sensitizes PARPi-resistant cells to PARPi.

6 citationstop 1%

humanproteomics

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedMay 13, 2026

TBK1 restricts IRGQ-mediated autophagy

Uxía Gestal Mato, Pauline Lascaux, Sergio Alejandro Poveda Cuevas…·Lina Herhaus

This study identifies TBK1 as a regulator of IRGQ-mediated autophagy by disrupting the IRGQ-GABARAPL2 complex through phosphorylation of GABARAPL2.

2 citationstop 2%

humanproteomics

𝕏 PostBluesky