Author

Derek P. Claxton

Vanderbilt UniversityORCID 0000-0002-1374-7176Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Derek P. Claxton1 paper

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alan D. CherringtoniD· 1 shared AUDREY LUCERNE· 1 shared Ben FarmeriD· 1 shared Chanel M Norphlet· 1 shared Dale S. EdgertoniD· 1 shared Emily M. HawesiD· 1 shared Guillaume KraftiD· 1 shared Hannah L. WatermaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

Alan D. CherringtonORCID

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2 papers

Recent·Most cited

Sequence determinants of pathogenicity in glucose-6-phosphatase linked to glycogen storage disease type 1a

Richard A. Stein, Emily M. Hawes, Chanel M Norphlet, Margaret H. Rakonick, Shelby A Harris, Trisha Sivam, AUDREY LUCERNE, Valentina R Da Silva, Richard M. O’Brien, Derek P. Claxton

The paper uses AlphaMissense and experimental assays to analyze 78 G6PC1 variants, identifying stability and allosteric modulation as key pathogenic mechanisms.

bioRxiv · Jul 28, 2026 · PreprintBiochemistry

Morning Glucagon Disrupts Insulin Induced Hepatic Metabolic Memory and Subsequent Afternoon Glucose Metabolism in Canines

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha C Yankey, Karin J. Bosma, R M O'Brien, Derek P. Claxton, Tristan Howard, Guillaume Kraft, Alan D. Cherrington, Dale S. Edgerton

This study investigates whether morning hyperglucagonemia affects the priming effects of morning hyperinsulinemia on subsequent hepatic glucose metabolism in dogs.

Frontiers in Endocrinology · Apr 29, 2026Peer-reviewedPhysiology