Avraham A. Levy

Features affecting Cas9-Induced Editing Efficiency and Patterns in Tomato: Evidence from a Large CRISPR Dataset

The paper analyzes a large CRISPR dataset in tomato to identify factors affecting Cas9 editing efficiency and repair patterns, finding chromatin accessibility and genomic context are key determinants.

A multi-omics approach to identify deleterious mutations in plants

This paper uses multi-omics data and machine learning to identify deleterious mutations in plants, showing improved performance over methods relying only on phylogenetic conservation.

Uncovering the Dynamics of Precise Repair at CRISPR/Cas9-induced Double-Strand Breaks

The paper quantifies CRISPR/Cas9-induced DSB dynamics and repair in tomato protoplasts, revealing that precise repair accounts for 40-70% of events, limiting editing efficiency.

A CRISPR-induced DNA break can trigger crossover, chromosomal loss and chromothripsis-like rearrangements

This study identifies CRISPR-induced genomic events like crossover, deletions, and chromothripsis-like rearrangements in plants using a LOH assay.

Independent evolution of transcript abundance and gene regulatory dynamics

The paper profiles gene expression in related yeast species across hundreds of conditions to distinguish transcriptional regulation from expression level variation, finding that promoter strength changes drive divergence without altering network positioning.

Large-scale rewiring in a yeast hybrid

The paper describes a yeast hybrid with increased growth rate and biomass yield under various conditions, but identifies genetic perturbations and regulatory disruptions associated with heterosis.