The RNA demethylase FTO targets m6Am in snRNA to establish distinct methyl isoforms that influence splicing
Jan Mauer, Miriam Sindelar, Vladimir Despic, Théo Guez, Ben R Hawley, Jean‐Jacques Vasseur, Andrea Rentmeister, Steven S. Gross, Livio Pellizzoni, Françoise Debart, Hani Goodarzi, Samie R. Jaffrey
This study shows FTO demethylates m2-snRNA to regulate splicing by controlling reversible methylation of snRNAs.
Nature Chemical Biology · Feb 18, 2019Peer-reviewedMolecular Biology