Shu-Cheng Chuang

The paper assembles and characterizes 2,110 human centromeres, revealing novel haplotypes, mobile element insertions, and mutation rate variation across chromosomes.

The paper sequences chromosome 21 centromeres in Down syndrome families, finding extreme size asymmetry in some cases and suggesting it may be a genetic risk factor.

This paper presents near-complete, haplotype-resolved assemblies of a pancreatic cancer genome and normal tissue, identifying extensive somatic variants and epigenetic changes in previously excluded regions.

This paper describes the creation of a 2 Mb human artificial chromosome (HAC) using a protein-only centromere seeding approach that bypasses genetic engineering of target cells.

The paper describes the discovery of a new Dickeya species, Dickeya ananae, based on genomic and phylogenetic analyses of strains isolated from pineapple plants.

The paper compares three Colletotrichum scovillei strains to identify genetic differences linked to virulence on chili pepper, finding gene losses and specific gene functions affecting growth and pathogenicity.