Sarah M. Groves

This study identifies a novel intermediate cell state and a regulatory network in SCLC that drives lineage plasticity and immunogenicity.

The paper develops and applies Cahn-Hilliard solvers to model biomolecular condensate dynamics, showing they match experimental behaviors of chromosomal passenger complex condensation.

The paper estimates protein copy numbers from mRNA data across 369 cell lines and applies it to reclassify breast cancer subtypes and predict viral receptor abundances.

This study shows SCLC cells exist in a continuum of plastic states rather than discrete subtypes, with gene expression patterns linked to cancer hallmarks and potential therapeutic targets.

The paper identifies four SCLC subtypes using a systems approach, with NEv2 being a new subtype, and finds master regulators and destabilizers using BooleaBayes.