Author

Abbie S. Ireland

Duke UniversityORCID 0000-0002-4178-7239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Darren R. TysoniD· 3 shared Trudy G. OliveriD· 3 shared Benjamin L. WittiD· 2 shared Sarah B. HawgoodiD· 2 shared Afshin DowlatiiD· 1 shared Alan J. SimmonsiD· 1 shared Alissa M. WeaveriD· 1 shared Andrew ElliottiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

Darren R. TysonORCID

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3 papers

Recent·Most cited

KLF4 promotes a KRT13+ hillock-like state in lung squamous cell carcinoma

Luke Izzo, Tony Reyes, Srijan Meesala, Abbie S. Ireland, Lisa B. Earnest-Noble, S S Yang, Hari Shankar Sunil, Xiao Chun Cheng, Nomi Tserentsoodol, Sarah B. Hawgood, Carolyn Glass, Edward F. Patz, Benjamin L. Witt, Darren R. Tyson, Kathryn A. O’Donnell, Trudy G. Oliver

The paper identifies a KRT13+ hillock-like cell state in LUSC, driven by KLF4, which contributes to therapeutic resistance and heterogeneity.

Cancer Research · Jun 18, 2026Peer-reviewedCancer Biology

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer

Abbie S. Ireland, Daniel A Xie, Sarah B. Hawgood, Margaret W. Barbier, Lisa Y. Zuo, Benjamin E Hanna, Scarlett Lucas-Randolph, Darren R. Tyson, Benjamin L. Witt, Ramaswamy Govindan, Afshin Dowlati, Justin C. Moser, Anish Thomas, Sonam Puri, Charles M. Rudin, , Trudy G. Oliver

The paper identifies basal cells as the origin of neuroendocrine-tuft-like tumors in SCLC, revealing lineage plasticity and transcriptional states that mirror human cancer and normal cell injury responses.

Nature · Sep 17, 2025Peer-reviewedCancer Biology

Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes

Sarah M. Groves, Geena V. Ildefonso, Caitlin O. McAtee, Patricia Midori Murobushi Ozawa, Abbie S. Ireland, Philip E. Stauffer, Perry T. Wasdin, Xiaomeng Huang, Yi Qiao, Jing Shan Lim, Jackie E. Bader, Qi Liu, Alan J. Simmons, Ken S. Lau, Wade Thomas Iams, , Vito Quaranta

This study shows SCLC cells exist in a continuum of plastic states rather than discrete subtypes, with gene expression patterns linked to cancer hallmarks and potential therapeutic targets.

Cell Systems · Aug 17, 2022Peer-reviewedSystems Biology