Julien Sage

Identification and inhibition of the Cyclin D Rb-docking interface that drives cell division

This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.

Transcriptional networks underlying tumour plasticity in small-cell lung cancer

This study identifies a novel intermediate cell state and a regulatory network in SCLC that drives lineage plasticity and immunogenicity.

THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle

This study identifies FAM53C as a regulator of the G1/S cell cycle transition, showing it interacts with DYRK1A and affects cell cycle progression in cultured cells and organoids.

Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer

The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.

T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T-cells

Combining TCE therapy with IL-2 enhances TCE efficacy in aggressive small-cell lung cancer and melanoma models with low target antigen density through T cell clonal replacement and CD8+ effector T cell differentiation.

T CELLS promote the growth of small-cell lung carcinoma via an IL-6/CD74 axis

The paper shows T cells promote SCLC growth through an IL-6/CD74 axis, and IL-6 blockade enhances immunotherapy effectiveness in SCLC.

Efficient and multiplexed somatic genome editing with Cas12a mice

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

Unified Tumor Growth Mechanisms from Multimodel Inference and Dataset Integration

The paper uses Bayesian multimodel inference to analyze tumor growth mechanisms in SCLC, finding that high lineage plasticity, not rare stem-like populations, drives tumor evolution.

Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes

This study shows SCLC cells exist in a continuum of plastic states rather than discrete subtypes, with gene expression patterns linked to cancer hallmarks and potential therapeutic targets.

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

The paper identifies four SCLC subtypes using a systems approach, with NEv2 being a new subtype, and finds master regulators and destabilizers using BooleaBayes.