Author

Dieter W. Heermann

Heidelberg UniversityORCID 0000-0002-3148-8382Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Assay:Hi-C· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Andreas HofmanniD· 2 shared Arnab BhattacherjeeiD· 2 shared David C. GraingeriD· 1 shared David ForrestiD· 1 shared David J. SherrattiD· 1 shared Fatema‐Zahra M. RashidiD· 1 shared Frédéric G. E. CrémazyiD· 1 shared Jarno MäkeläiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

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10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Andreas HofmannORCID

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4 papers

Recent·Most cited

Uncovering High-Resolution Organization of Genomic Loci using Experimentally Informed Polymer Model

Rahul Mittal, Dieter W. Heermann, Arnab Bhattacherjee

This study introduces a polymer physics-based model integrating contact data and nucleosome positioning to reveal structural differences between active and inactive chromatin states in human genomic loci.

bioRxiv · Nov 19, 2025 · PreprintBiophysics

VECTOR: A Framework to Identify and Quantify Structural Changes in Chromatin using Hi-C Data

Kavana Priyadarshini Keshava, Dieter W. Heermann, Arnab Bhattacherjee

VECTOR quantifies chromatin structure from Hi-C data using Von Neumann entropy and graph spectral theory, outperforming existing tools in detecting structural changes across biological conditions.

bioRxiv · Sep 24, 2025 · PreprintBiophysics

The environmentally-regulated interplay between local three-dimensional chromatin organisation and transcription of proVWX in E. coli

Fatema‐Zahra M. Rashid, Frédéric G. E. Crémazy, Andreas Hofmann, David Forrest, David C. Grainger, Dieter W. Heermann, Remus Thei Dame

The paper provides in vivo evidence that NAP-mediated chromosome re-modelling regulates transcription of the osmoresponsive proVWX operon in E. coli by destabilizing and re-establishing H-NS bridges under hyperosmotic conditions.

Nature Communications · Nov 17, 2023Peer-reviewedMolecular Biology

Self-organised segregation of bacterial chromosomal origins

Andreas Hofmann, Jarno Mäkelä, David J. Sherratt, Dieter W. Heermann, Séan Murray

The paper proposes a self-organising model explaining how bacterial chromosomal origins are positioned and partitioned during the cell cycle, showing agreement with experimental data.

eLife · Aug 9, 2019Peer-reviewedBiophysics