David Forrest

The paper shows that promoters and terminators in bacteria are often coupled, with termination sequences contributing to promoter function, leading to regulatory interference between adjacent transcription units.

This study identifies H-NS as a transposon capture protein that directs transposition to specific chromosomal regions, affecting phenotypic diversity and gene function in bacteria.

The paper provides in vivo evidence that NAP-mediated chromosome re-modelling regulates transcription of the osmoresponsive proVWX operon in E. coli by destabilizing and re-establishing H-NS bridges under hyperosmotic conditions.

The paper shows that prokaryotic promoters often drive divergent transcription due to symmetric elements and reciprocal stimulation between transcription start sites.