Multi-modal, Label-free, Optical Mapping of Cellular Metabolic Function and Oxidative Stress in 3D Engineered Brain Tissue Models
Yang Zhang, Maria G. Savvidou, Volha Liaudanskaya, Varshini Ramanathan, Thi Tho Bui, Matthew Lindley, Yuhang Fu, Ash Sze, Ugochukwu O. Ugwu, Matthew E. Dilsizian, Xinjie Chen, Sevara Nasritdinova, Aonkon Dey, Eric L. Miller, David Lee Kaplan, Irene Georgakoudi
This study develops a label-free optical method to assess metabolic function and oxidative stress in 3D brain tissue models using spectral imaging and fluorescence lifetime analysis.
Communications Biology · Dec 2, 2025Peer-reviewedBioengineering