Irene Georgakoudi

Multi-modal, Label-free, Optical Mapping of Cellular Metabolic Function and Oxidative Stress in 3D Engineered Brain Tissue Models

This study develops a label-free optical method to assess metabolic function and oxidative stress in 3D brain tissue models using spectral imaging and fluorescence lifetime analysis.

Rapid, high-resolution, non-destructive assessments of metabolic and morphological homogeneity uniquely identify high-grade cervical precancerous lesions

This paper uses two-photon microscopy to detect high-grade cervical precancerous lesions with high sensitivity and specificity by analyzing metabolic and morphological features.

Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model.

This study investigates mitochondrial dysregulation's role in neurodegeneration after contusion injury using a 3D in vitro triculture model of human brain cells.

Riboflavin Depletion Promotes Longevity and Metabolic Hormesis in Caenorhabditis elegans

This study shows that riboflavin depletion in C. elegans extends lifespan and improves metabolic health through multiple pathways.

Multimodal Analyses of Stable Vitiligo Skin Identify Tissue Interactions That Control Disease Persistence

The paper identifies keratinocyte subpopulations in stable vitiligo skin that drive disease persistence through CXCL signaling and altered metabolism.