Michał Ma̧czewski

Pulmonary pressure load shapes right ventricular molecular remodelling in dilated cardiomyopathy

This study identifies molecular changes in right ventricular tissue from DCM patients, showing that pulmonary pressure load drives transcriptional remodelling and fibrosis, while proteomic changes reflect immune activation and metabolic shifts.

Dysferlin is a novel regulator of COMP-positive matrifibrocytes in heart failure

This study identifies dysferlin as an antifibrotic regulator that limits fibroblast differentiation and myocardial fibrosis in heart failure.

Infarctsize-AI: an efficient infarct size image analysis tool for small rodent myocardial infarction studies

Infarctsize-AI reduces time and inter-observer variability in infarct size analysis of rodent myocardial infarction studies using deep learning.

Renal cancer cell-derived amphiregulin recruits mesenchymal stromal cells, induces their glycolytic switch, and promotes tumour growth

This study shows renal cancer cells secrete amphiregulin, recruiting MSCs and inducing their glycolytic switch, which supports tumour growth.