Explore synergistic and competitive miRNA regulation mechanisms in the miRNA-mRNA regulatory network from the information decomposition perspective
Chu Pan, Jing Jiang, Limei Jing, Wangqing Chen, Yi Yang, Ying Liu, Jiawei Luo, Xiangxiang Zeng
The paper quantifies synergistic and competitive miRNA interactions using multivariate information measurement, finding that neighboring and overlapping binding sites on mRNA lead to synergistic and competitive effects, respectively.
bioRxiv · Dec 20, 2021 · PreprintBioinformatics