Hong‐Wen Deng

The paper identifies new gain-of-function HER2 mutations using a high-throughput assay and links them to improved patient survival.

This study shows that the small molecule inhibitor WAY262611 inhibits osteosarcoma metastasis by activating Wnt signaling and inducing osteoblastic differentiation.

The paper develops M2AE, a multi-task multi-view model to impute blood SCFA levels using gut metagenomic data, dietary features, and host characteristics, showing improved performance over existing methods.

This paper introduces DemoVAE, a variational autoencoder that generates synthetic fMRI data conditioned on demographics and removes demographic confounds from fMRI features.

omicsMIC benchmarks 28 imputation methods for mass spectrometry-based omics data, enabling researchers to evaluate and select methods based on real-time visualizations.

MIMOSA improves DNA methylation prediction and MWAS power by integrating summary-level mQTL data, identifying more CpG-phenotype associations in whole blood.

This study identifies Acebutolol and Amiloride as potential osteoporosis treatments through multi-omics analyses and zebrafish experiments.

The paper prioritizes regulatory SNPs from obesity GWAS by analyzing epigenomic and transcriptomic features in adipose tissue, identifying 47 potential causal SNPs across 14 genes.

This study identifies three human osteoblast subtypes using scRNA-seq, revealing a novel subtype with unique gene expression and functional roles in bone and hematopoiesis.

This study identifies 16 novel regulatory SNPs associated with osteoporosis risk by integrating epigenomic and transcriptomic data from GWAS.

This paper introduces a gene-level methylome-wide association analysis method called CMO that identifies novel Alzheimer's disease genes by integrating DNA methylation and enhancer-promoter interactions with GWAS data.

The paper identifies regulatory SNPs in TBX15 that influence both obesity and osteoporosis risk through epigenetic and genetic analysis of GWAS data.

The paper establishes that ZP1 mutations cause zona pellucida absence and female infertility in both rats and humans by sequestering ZP3 and ZP4 intracellularly.

This study identifies 67 pleiotropic genes shared across seven autoimmune diseases using multivariate analysis and validates their associations with genetic risk.