Author

Hong‐Mei Xiao

Central South UniversityORCID 0000-0002-8121-9498Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:fine-mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Hong‐Wen DengiD· 4 shared Hui SheniD· 2 shared Jonathan GreenbaumiD· 2 shared Lijun TaniD· 2 shared Chao Lv· 1 shared Cui Zhou· 1 shared Danyang LiuiD· 1 shared Hang-Jing Tan· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBioinformatics

Hong‐Wen DengORCID

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Author profile →

4 papers

Recent·Most cited

Multi-omics analyses of drug repurposing reveal Acebutolol and Amiloride for osteoporosis treatment

Danyang Liu, Jonathan Greenbaum, Qiaorong Yi, Shuang Liang, Yue Zhang, Jiachen Liu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Lijun Tan, Hong‐Wen Deng

This study identifies Acebutolol and Amiloride as potential osteoporosis treatments through multi-omics analyses and zebrafish experiments.

bioRxiv · May 3, 2022 · PreprintSystems Biology

Epigenomic and transcriptomic prioritization of candidate obesity-risk regulatory GWAS SNPs

Xiao Zhang, Tianying Li, Hong‐Mei Xiao, Kenneth C. Ehrlich, Hui Shen, Hong‐Wen Deng, Melanie Ehrlich

The paper prioritizes regulatory SNPs from obesity GWAS by analyzing epigenomic and transcriptomic features in adipose tissue, identifying 47 potential causal SNPs across 14 genes.

International Journal of Molecular Sciences · Jan 23, 2022Peer-reviewedBioinformatics

A systematic dissection of human primary osteoblasts in vivo at single-cell resolution

Yun Gong, Junxiao Yang, Xiao‐Hua Li, Cui Zhou, Yu Chen, Zun Wang, Xiang Qiu, Ying Liu, Huixi Zhang, Jonathan Greenbaum, Liang Cheng, Yihe Hu, Jie Xie, Xuecheng Yang, Yusheng Li, , Hong‐Wen Deng

This study identifies three human osteoblast subtypes using scRNA-seq, revealing a novel subtype with unique gene expression and functional roles in bone and hematopoiesis.

Aging · Aug 24, 2021Peer-reviewedBioinformatics

Mutant Zp1 results in Zona Pellucida Lacking and Female Infertility in Rats and Humans

Chao Lv, Hualin Huang, Yan Wang, Tianliu Peng, Hang-Jing Tan, Ming-Hua Zeng, Ruping Quan, Hong‐Wen Deng, Hong‐Mei Xiao

The paper establishes that ZP1 mutations cause zona pellucida absence and female infertility in both rats and humans by sequestering ZP3 and ZP4 intracellularly.

bioRxiv · Oct 30, 2019 · PreprintGenetics