Nutritional Access Modulates Activity of a Small Molecule Enhancer of Endosomal Escape
Sten Oskar Vilhelm Wilhelmson-Anden, Hampus Du Rietz, Hampus Hedlund, Johanna M. Johansson, Wahed Zedan, Anders Wittrup
The paper shows that glucose depletion enhances chloroquine-induced endosomal membrane damage in tumor cells, improving siRNA efficacy.
bioRxiv · Feb 4, 2026 · PreprintCancer Biology