Miki Umetani

This study shows that antibiotic resistance in E. coli emerges rapidly in single cells under chloramphenicol exposure through phenotypic heterogeneity and gene expression remodeling.

The paper uses Raman spectroscopy to reveal a low-dimensional stoichiometry-conserving proteome structure across bacterial and human cells, showing its role in maintaining homeostasis and enabling adaptation.

The paper shows that Escherichia coli can adapt to lethal genetic modifications under antibiotic exposure by restoring growth without additional mutations, but this adaptation depends on timing and environmental history.