Edo L. Kussell

This study shows that antibiotic resistance in E. coli emerges rapidly in single cells under chloramphenicol exposure through phenotypic heterogeneity and gene expression remodeling.

The paper investigates how fluctuating environments shape gene regulatory networks by analyzing the impact of regulation on fitness under metabolic fluctuations.

The paper shows transposon-plasmid nesting allows microbes to rapidly respond to environmental changes by combining genetic mobility with copy number amplification.

This paper introduces a framework to measure selection on cellular lineages and traits by expanding population growth rates using fitness cumulants, showing their relevance in regrowing processes.

The paper develops a theoretical framework to explain exponential growth in nonlinear reaction networks, showing how scalability of flux functions and ergodicity of rescaled systems lead to various growth modalities.

The paper quantifies fitness landscapes and selection on phenotypic states using single-cell genealogical data from bacterial populations under antibiotic stress.